How To Switch From Finasteride To Dutasteride

How To Switch From Finasteride To Dutasteride – Finasteride (commonly known as Propecia) and dutasteride (also known as Avodart™) are both oral medications used to treat pattern baldness and benign prostatic hyperplasia. Although these pills work in the same way and are used to treat the same conditions, there are very important differences between them.

Finasteride is the only oral medication approved by the FDA for the treatment of male pattern baldness. Finasteride was first used to treat benign prostatic hyperplasia (BPH) in 1992, according to Stat Pearls Publishing. A few years later, in 1998, it was also approved to treat androgenetic alopecia.

How To Switch From Finasteride To Dutasteride

How To Switch From Finasteride To Dutasteride

Finasteride is available as a generic drug, but you may be more familiar with its brand name Propecia®. People taking finasteride only need 1 mg per day to prevent baldness.

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Although it is not readily available or FDA-approved, topical finasteride is emerging as a particularly popular alternative to oral finasteride. A review in the Journal of Dermatological Drugs reported that the topical solution was as effective as oral finasteride, but caused fewer side effects.

Dutasteride is commonly known as Avodart™, although it has different names when combined with other drugs in a single capsule or pill. Like finasteride, dutasteride has been around since the 1990s. But it was only approved to treat BPH in 2001, according to a report by the Japan Agency for Drugs and Medical Devices.

Dutasteride is not yet approved for the treatment of androgenetic alopecia in the United States, but it is now available in Japan and South Korea. As a stronger drug, the dosage of dutasteride is lower than that of finasteride. A report by the Japan Medicines and Medical Devices Agency states that the usual dose is only 0.1 mg of dutasteride per day, but this dose can be increased to 0.5 mg as needed.

Compared to finasteride, dutasteride lotion or other topical solutions have not been extensively tested in clinical practice. However, articles in the Journal of the European Academy of Dermatology and Venereology and ACTAS Dermo-Syphiliographicas discuss the success of microinjection of dutasteride directly into the scalp.

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Few of these studies so far suggest that low-dose weekly or monthly injections of dutasteride can help improve hair growth. Like topical finasteride, topical microinjection of dutasteride also produces fewer and milder side effects.

Both dutasteride and finasteride are hormone blockers and are DHT (dihydrotestosterone) blockers. Although it is perfectly normal and safe to have DHT in the body, this androgen has been linked to baldness and prostate problems. Therefore, blocking DHT makes both finasteride and dutasteride useful as drugs for androgenetic alopecia and BPH.

DHT is thought to be the main hormone involved in androgenetic alopecia. When it binds to the hair follicle, it causes gradual and progressive hair loss. Reducing levels or preventing this androgen from binding to hair follicles can help stop baldness and prevent the condition from developing.

How To Switch From Finasteride To Dutasteride

DHT blockers do exactly what their name suggests. But finasteride and dutasteride do this in two slightly different ways. In fact, this is the main difference between these two drugs.

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DHT is produced primarily by testosterone through the 5-alpha reductase (5-alphaR) family of enzymes, according to a study in the journal Skin Accessory Disorders. Most, if not all, DHT blockers work by targeting part of the 5-αR enzyme family.

There are three members of the 5-αR family: type I, type II, and type III. All three of these enzymes are called isozymes and are found in different areas of the body. For example, type I is mainly found in hair follicles and skin, while type II is mainly found in men’s genitals, including their prostate. Types I and II are thought to be the main isoenzymes involved in diseases such as BPH and type 2 baldness.

Finasteride primarily blocks DHT by targeting type II isoenzymes of the 5-αR family. Dutasteride, on the other hand, is able to target all three isoenzymes. While finasteride is able to block about 70% of DHT serum levels, dutasteride blocks about 90% of DHT, making it a more effective DHT blocker.

Dutasteride is now known to be a more potent DHT blocker than finasteride. Still, the FDA has shown no signs of approving a more potent drug to treat androgenetic alopecia.

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According to a meta-analysis of clinical interventions in the elderly, dutasteride is superior to finasteride in the treatment of androgenetic alopecia. Dutasteride was found to be superior to finasteride in improving total hair count, scalp hair, hair regrowth at the temples and crown, and participant evaluations of its treatment.

It is not surprising that dutasteride produces better results, as this drug blocks more DHT than finasteride. The same doses of these drugs are not required. The study specifically looked at a 0.5 mg dose of dutasteride and a 1 mg dose of finasteride.

Dutasteride is more potent and effective as a DHT blocker, but it has a longer half-life than oral drugs, lasting about 4 to 5 weeks. This means that once you take dutasteride, it stays in your body for a while and takes a long time to get out of your body.

How To Switch From Finasteride To Dutasteride

Although this does not seem positive, it means that dutasteride is a more favorable treatment for hair loss than finasteride. Finasteride has a half-life of 6-8 hours and needs to be taken once a day. With such a long half-life, dutasteride can be taken less often and still be effective, making it an ideal hair loss treatment for busy or forgetful men.

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“Patients who forget to take dutasteride do not experience DHT relapse, as well as patients who miss a dose of finasteride. This increases the possibility of developing a new formulation of the drug, for example, that needs to be administered only once a week.

Leonard Marks, MD, assistant professor of urology at UCLA and medical director of the Urology Research Foundation, is published in Urology Times.

Finasteride does not work for everyone, this is to be expected. After all, no drug is 100% effective.

Since both dutasteride and finasteride work as DHT blockers, you might think that if one doesn’t work, the other won’t. But that’s not always the case. A study in the International Journal of Dermatology reported that 77 percent of participants (all men who did not respond to finasteride treatment within 6 months) saw hair regrowth after taking dutasteride.

Topical Finasteride Before And After Results

If you feel that finasteride is not working for you, switching from finasteride to dutasteride is definitely an option. However, if you are not in Korea or Japan, your doctor may need to prescribe dutasteride for off-label use as a hair loss treatment.

In general, you are more likely to end up with more side effects when you are taking a stronger drug. However, when oral dutasteride was compared to oral finasteride, a meta-analysis in clinical interventions in the elderly found that the two drugs caused approximately the same side effects. The incidence of these side effects is similar between finasteride and dutasteride.

Dutasteride is definitely a promising and effective hair loss treatment for androgenetic alopecia. Keep in mind that it is not as well researched as finasteride and is not formulated. Additionally, few studies have directly addressed finasteride and dutasteride as hair loss treatments, meaning more comparative studies of the two drugs are needed.

How To Switch From Finasteride To Dutasteride

Both finasteride and dutasteride are considered safe drugs. However, both have side effects. The exact side effects vary depending on how and when you take the drug.

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The side effects of oral finasteride and oral dutasteride are very similar. These side effects are usually sex-related and include problems such as erectile dysfunction, decreased libido and ejaculation disorders, according to the Journal of Clinical and Aesthetic Dermatology. Between 3% and 16% of people experience these side effects.

Oral finasteride is notorious for its side effects—many of which are sexual. Generally, three main types of side effects are discussed: changes in libido, erectile dysfunction and ejaculation problems. Interestingly, these side effects go away in people who take the drug for a long time.

A small group also reported more severe symptoms. These serious side effects are often grouped together under the category of post-finasteride syndrome.

A report published in the BMJ states that side effects after finasteride syndrome may be related to cognition, sexuality and mood. They include (but are not limited to) cognitive fog and memory impairment, breast tissue growth, muscle weakness, fatigue, anxiety, insomnia and depression. In addition to the typical side effects that occur while taking this medication, the side effects following finasteride syndrome may also occur.

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Although these side effects may sound very serious, it is important to realize that post-finasteride syndrome only affects a small number of users. The Post-Finasteride Syndrome Foundation estimates that about 1 percent of people taking finasteride may experience these symptoms. Young users appear

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