How To Play Mexican Sweat
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How To Play Mexican Sweat
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Acceptance Date: May 29, 2020 / Revision Date: July 4, 2020 / Acceptance Date: July 12, 2020 / Release Date: July 29, 2020
Today, wearable devices are at the forefront of both academic research and industry, and many wearable devices have been put into the market. One of the latest developments in biosensing wearable technology is the field of remote monitoring of human health through skin detection. However, all wearable devices on the market today still provide information unrelated to human metabolites and/or disease biomarkers, except for the known status of continuous glucose monitoring in diabetic patients. Furthermore, even in the latter case, the glucose level in the blood is obtained subcutaneously rather than on the skin. Human sweat, on the other hand, has been shown to be very rich in molecules and other biomarkers (such as ions), which makes sweat an interesting human fluid for collecting medical information at the molecular level in a completely non-invasive way. method. Of course, proper collection of sweat above the skin is required to properly transport this fluid to the molecular biosensors on board the wearable system. In this case, the microfluidic system effectively leverages wearable sensors. These devices were originally fabricated using methods such as photovoltaics and chemical etching techniques using solid materials. Today, methods of fabricating microfluidic systems are moving towards 3D printing methods. These methods overcome some of the limitations of previous methods, including being expensive and inflexible. 3D printing methods are characterized by high speed and, depending on the application, the use of a variety of materials to control the texture and mechanical properties of objects in a cheaper manner. Therefore, the purpose of this paper is to review all recent advances in 3D printing methods for fabricating wearable fluids and provide a key framework for the future development of wearable devices that can remotely monitor human metabolism directly on the device. -leather.
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Wearable metabolic biosensors; remote monitoring; sweating; microfluidics. Biosensors for 3D printing; metabolism; remote monitoring; sweating; microfluidics. 3D printing
Currently, disease prevention through early monitoring, once the disease is fully developed, is a very cost-effective approach in terms of treatment costs. This new approach could also lead to better health outcomes [1, 2]. In this effort, wearable biosensors have received great attention. The high characteristics, portability, fast detection, low cost, and low power consumption of biosensors make biosensors very suitable as wearable applications. Wearable devices play an important role in achieving these goals, as the collection of important information can be easily accessed in a continuous and non-invasive manner [3, 4, 5, 6, 7, 8, 9]. The United States declared 2015 the Year of Wearables in Healthcare, while The Huffington Post reported that wearable technology is the next revolution in healthcare. Wearable biosensors are moving towards non-invasive monitoring. In this regard, microfluidic systems are very efficient and useful. Due to the important role of microfluidics, fabrication methods need to be tailored to these goals. Therefore, efficient, flexible, fast, and affordable fabrication methods play a huge role in the future development of wearable biosensors and human health monitoring. Before discussing fabrication methods, we will first discuss wearable technology, its application in health monitoring, and the role of microfluidics in its development.
Wearable technology generally refers to a class of wearable devices that consumers can wear directly for fun or simply to track their physical activity and health. Another class of wearable technology is wearable medical devices, which patients can wear on their skin, on different parts of the body, and often involve tracking health-related body physiology information, in some cases, at the molecular level  , 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24]. Wearable devices can collect data 24 hours a day, 7 days a day in many environmental settings as people go about their daily lives at home or at work . Wearable devices are capable of transmitting physiological information as the body develops health and disease states. They can help people to self-monitor without expensive equipment and without the need for educated professionals or expensive teams of medical personnel [15, 26]. Furthermore, the characterization of non-invasive and wearable technologies for diagnosis is very useful for both continuous health monitoring and early and pre-disease prognosis. It also enables patients to quickly access clinical information, thereby encouraging people to take care of their health in a more convenient and less expensive way, which also improves adherence [27, 28]. In recent years, many wearable devices have been proposed in the scientific literature to collect body physiological data, especially for personalized medicine and point-of-care diagnosis , as well as home and fitness monitoring. Wearable watches through shirts , necklaces , tattoos , lenses , headbands , smart bracelets , watches , shoes , glasses  provided 39], bracelets and spots [40, 41]. Various types of wearable sensors are used for clinical diagnosis by measuring key electrolytes, metabolites, ions, acids, heavy metals, alcohol, and toxic gases directly obtained in various body fluids [25, 42], as shown in Figure 1.
When considering different ways to sample human particles, there are many candidate body fluids (Figure 2). Blood is the most used biological fluid in clinical diagnosis. Access is often painful, difficult to access using non-surgical techniques, and often impossible when trying to use a wearable pad . Collecting them is usually not painful, but may also induce phobias and cause discomfort to the patient . Sampling is usually invasive and not suitable for long-term continuous monitoring . As an alternative to blood sampling, interstitial tissue was considered, another option for commercially available blood glucose meters mainly used in diabetic patients. To harvest glucose from the interstitial tissue, we usually still need to go through the skin, so this method is also invasive. In the case of certain metabolites, blood is not necessarily useful for health monitoring, so it is possible to transfer from blood to other bodily fluids such as saliva, sweat and tears for health monitoring. It provides a non-invasive and on-site monitoring method, which is more attractive for long-term application of continuous health monitoring in daily life .
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Tears are promising fluids for the detection of proteins, lipids and glucose. Tear sampling or its continuous monitoring can be inconvenient or risky in terms of irritation, which can lead to side effects as well as misleading sensor readings (eg, through differences in pH). Capillary pipettes and spatulas are commonly used for tear sampling. When in use, the eye usually responds when approaching a foreign object, and some unwanted contact can cause irritation and make sampling uncomfortable. On the other hand, any stimulus that increases tear production results in a decrease in biomarker concentrations. Saliva contains signs of various diseases, such as cardiovascular disease, oral and breast cancer, and human immunodeficiency virus (HIV) [46, 47, 48]. It provides limited physiological insight due to significant changes in the saliva composition of the last meal. In contrast, sweat is a promising wearable sensing fluid and provides various analytes such as ions, alcohol, and drugs .
Sweat is particularly interesting for non-invasive biosensing because it is a rich source of information about internal physiological health, which can be determined by
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